Among 28 chemokine genes available, <i>CXCL9/10/11/CXCR3, CXCL13/CXCR5 and XCL1/XCR1</i> mRNA expression were significantly increased in RCC compared to normal kidney tissue and also strongly associated with tumor-infiltrating effector memory and central memory CD8<sup>+</sup> T cells in all investigated collectives. This evidence concerns the gene XCR1 and neoplasm.