Chemokine (C-X-C motif) ligand 8, also known as IL-8, highly expressed in various tumors, including colon, ovarian, breast, pancreatic, prostate, and hematological malignancies (104–106), has been demonstrated that could recruit MDSCs to tumor sites via CXCR1/CXCR2 (107). The gene discussed is CXCL8; the disease is neoplasm.