In the current study, the results demonstrated that DOF-W exhibited promising antioxidant capacity (DPPH, ABTS, FRAP, intracellular ROS level in NHEK cells), anti-COX-2 effect, anti-glycation potency (inhibition of non-enzymatic glycation reaction and inhibition of CML expression in fibroblasts), and anti-aging effect (SA-β-gal staining test and collagen expression in fibroblasts). The gene discussed is PTGS2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.