CCL2 and neoplasm: β2AR signaling can also polarize macrophages from M1 to M2 type, thereby enhancing anti-inflammatory cytokines like IL-10, IL-4 & IL-13, and decreasing pro-inflammatory cytokines like INFγ, TNFα, IL1β, CCL2, CCL3 and CCL4 to cause tumor progression (35–39).