NFKB1 and Rotavirus infection: Comparison of anti-rotavirus drugs ibuprofen, NAC, and pioglitazone which all interfere with the NF-kB pathway showed that NAC was the most promising drug for the treatment of rotavirus infection in children, and the expression level of hsc70 and PDI in cells of the drug-treated group returned to the level of the uninfected virus group (62).