Moreover, GSEA, including KEGG (Figure 4C) and Reactome (Figure 4D) pathways, showed significant enrichment in a series of signaling pathways involved in the regulation of glioma malignant progression and the tumor microenvironment, including the cell cycle, extracellular matrix organization, cytokine-cytokine receptor interaction and p53 signaling pathways. Here, TP53 is linked to central nervous system cancer.