By bacterial depletion using oral antibiotics prior to the 1.5% DSS challenge (Figure 3C), the clinical signs of colitis, such as body weight loss, DAI score, and colon length shortening, were recovered in Sult2b1−/− mice to the levels similar to those in Sult2b1+/+ mice (Figures 3D–F). This evidence concerns the gene SULT2B1 and colitis.