Cell migration involves complex physiological transduction mechanisms, and blocking mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/serine-threonine protein kinase (AKT), NF-κB, and other signaling pathways is currently thought to inhibit the cell migration process associated with RA-FLS (147, 148). This evidence concerns the gene AKT1 and rheumatoid arthritis.