Activated FLSs in RA can express VEGF, angiopoietins, etc., as major players in the process of angiogenesis (95), and other matrix remodeling transcripts such as MMP-1 and TGF-β1 have been shown to be synchronously upregulated with FAP in dedifferentiated mature adipocytes (96). The gene discussed is FAP; the disease is rheumatoid arthritis.