Other excellent functional investigations reported in this paper revealed that CAF produced SDF-1(encoded by CXCL12 gene) and TGF-β that through their cognate receptors CXCR4 and TGFBRII activate SRC kinase phosphorylation/Zeb1 axis altogether mediating tumor cell cluster formation that are also detected as CTC clusters. The gene discussed is CXCL12; the disease is neoplasm.