In turn, disruption of platelets interactions with cancer cell by S-nitrosocaptopril (CapNO) inhibits adhesion to endothelial cells and lung cancer metastasis in immunocompetent mouse models through multiple mechanisms including reduction of Sialyl-Lewis X (Slex) levels in cancer cells and ADP-induced P-selectin in platelets, IL-1b induced VCAM1, ICAM-1, and E-selectin by HUVECs (33). This evidence concerns the gene ICAM1 and lung cancer.