As it is discussed in the previous sections, the formation of the CTC clusters and metastasis in particular cancers depend on IL1R1 (16), IL6, NODAL, NOTCH1 (17), CD44 (14), CXCR4 (4), TGFBR2 (4), CDH1 (4, 28), EPCAM (29), ICAM1 (30), and CCR1 (31). The gene discussed is NODAL; the disease is cancer.