Compared to the infected epithelial monocultures, infection of the co-culture model resulted in a significant increase in the apical secretion of IFNγ (p<0.0001), IL1-β (p<0.05), IL-6 (p<0.0001) and IL-10 (p<0.001) (Figure 1B) and in the basolateral secretion of IFNγ (p<0.05), IL-4, IL-6 both (p<0.0001), IL1-β, IL-10 and TNFα (all p<0.001) (Figure 1C). The gene discussed is IL6; the disease is infection.