As a proof of concept, we selected the twelve most EoE-contributing plasma immune components (IgE, IgG4, CXCL12, sTNFR1) and metabolites (pyridoxine, 4-pyridoxic acid, N-acetyl-DL-tryptophan, thymine, 3-hydroxybutyric acid, gamma-butyrolactone, hexanoylcarnitine, alanine) identified through mono- and multi-blocks analysis and performed a PLS-DA modelling, with EoE status as the explicative variable. The gene discussed is CXCL12; the disease is eosinophilic esophagitis.