At the same time, the upregulation of PD-L1 on dendritic cells inhibits the secretion of IL-2, IL-10, INF-γ, INF-α and other cytokines by T lymphocytes in the tumor microenvironment, downregulates the immune “surveillance” function of T cells, and mediates tumor immune escape (32–34). This evidence concerns the gene IL10 and neoplasm.