Moreover, further analysis was made to investigate the mRNA expression level of CRGs between normal and CRC samples, and we found that the expressions of FDX1, DLD, DLAT, PDHB, and MTF1 were significantly decreased, whereas LIPT1, GLS, and CDKN2A were significantly upregulated in tumor samples (Figure 1E). Here, CDKN2A is linked to colorectal carcinoma.