Through bioinformatics study of gene expression changes in LUAD patients after being treated by cisplatin that the data was downloaded from GEO dataset, it was found that cisplatin could regulate the abnormal decrease or increase of gene expression level of BTG2 and SerpinB5 in Lung cancer cells, and these two genes were related to the overall survival (OS) of the LUAD patients. This evidence concerns the gene BTG2 and lung cancer.