Since hypoxia is associated with increased lipolysis, increased FFA levels in the blood (26), and impaired FFA β-oxidation (22, 23), and p300 functions as a co-activator for PPARα (38), hepatic HIF1α and/or HIF2α might be involved in the declined PPARα signaling during sepsis. The gene discussed is EPAS1; the disease is Sepsis.