IKZF3 and systemic lupus erythematosus: Immunomodulatory imide drugs (IMiDs) such as thalidomide and its derivatives lenalidomide, pomalidomide, and Iberdomide (CC-220) act as molecular glue degraders to promote the ubiquitination and degradation of IKZF1 and IKZF3 by CRL4CRBN, ultimately relieving the symptoms of SLE (134, 137, 138, 182) (Table 1).