Previous studies suggested that the F-box and WD repeat domain-containing 7 (FBW7), as a substrate receptor (SR) of SKP1–Cul1–F-box (SCF), was predominantly upregulated in the colon tissues of patients with inflammatory bowel disease (IBD) and was correlated with its severity (25, 26). The gene discussed is FBXW7; the disease is inflammatory bowel disease.