For instance, SCFFBW7 functions as a regulator of AIDs in the following aspects: 1) promoting the degradation of IκB, EZH2, and MCL-1; 2) accelerating the pro-inflammatory NF-κB signaling pathway; 3) promoting the recruitment of MPhs into colitis-affected colon tissues; 4) increasing the apoptosis of macrophages and neutrophils; and 5) leading to the accumulation of immune complex and inducing the aggravation of SLE (25, 26, 141). Here, NFKB1 is linked to systemic lupus erythematosus.