CUL4A and hepatocellular carcinoma: Furthermore, a study on hepatocellular carcinoma (HCC) showed that the long non-coding RNA (lncRNA) uc.134 can inhibit the Cul4A-mediated ubiquitination and degradation of LATS1 and promote the phosphorylation of LATS1; moreover, it activates the Hippo pathway to suppress the cell proliferation of HCC (95).