We also identified CCL3 and TSLP as cytokines that were more highly secreted from fibroblasts isolated from load‐bearing joints (knees, hips, foot) compared to the non‐load‐bearing hand joint but were not differentially secreted by obesity, which might be indicative of their induction in response to load‐induced cartilage damage. The gene discussed is TSLP; the disease is obesity due to melanocortin 4 receptor deficiency.