Finally, in the foot joint the identified obesity‐associated DEGs were significantly aligned to the canonical pathways ‘CD40 signaling’, ‘senescence’ and several ‘apoptosis’ signaling pathways (Figure 2K) with predicted activated USRs of senescence, cell cycle/ growth arrest (E2F4) and inhibited USRs of apoptosis (TGM2, TNF and IFNG). Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.