SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: No difference in the SCN1A-encoded variant residue location within the protein sequence was seen between missense variants identified in the Dravet syndrome cohort compared with the GEL SCN1A control cohort (Supplementary Table 1, Supplementary Table 4 and Supplementary material 13).