SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: This individual with Dravet syndrome and a likely pathogenic splicing variant in SCN1A (NM_001165963:exon22:c.3706-2A>G), has left temporal lobe focal cortical dysplasia (FCD) (Fig. 3A), and ictal scalp EEG recordings consistently demonstrating that many of his seizures are of left temporal onset (see Supplementary material 17, for full details).