SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Even amongst family members segregating one pathogenic SCN1A variant, the severity of the seizure phenotype can be wide-ranging, suggesting a contribution of additional genetic variation to the phenotype.65 Therefore, we hypothesized that the PRS for epilepsy would be higher in individuals with Dravet syndrome compared to GEL epilepsy and GEL controls.