PRS for intelligence was lower but not significant (adjusted P = 0.033, at PT = 10−4, Tukey’s test) (Fig. 5A), PRS for longevity was higher but not significant (adjusted P = 0.049, at PT = 10−2, Tukey’s test) (Fig. 5B), and PRS for epilepsy was higher but not significant (adjusted P = 0.28, at PT = 10−1, Tukey’s test) in the Dravet syndrome cohort compared with the GEL SCN1A controls (Fig. 5C). Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.