Therefore, the difference in the cool environment may be attributed to the lower Tgi, Tsk and Tb of the participants with paraplegia, as reduced body heat content is known to significantly attenuate CIVD reactions (Daanen and Ducharme 1999; Daanen et al. 1997; Flouris and Cheung 2009b; Flouris et al. 2008). This evidence concerns the gene TSKU and paraplegia.