Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) encodes a receptor of TNFSF12/TWEAK, whose engagement could induce TNF receptor-associated factor (TRAF) binding to the cytoplasmic tail of TNFRSF12A and then activate intracellular signal transduction cascades, such as the NF-κB pathway [33], STAT3/5 pathway, AKT2 pathway [34], etc. TNFRSF12A promotes glioma cell migration, invasion, and resistance to chemotherapeutic agents [35]. Here, STAT3 is linked to central nervous system cancer.