However, since the target proteins and downstream signaling pathways of miR-17-5p are complex under hyperglycemic and hypoxic conditions, our study on the mechanism of miR-17-5p-enriched EPC-EXs did not exclude other targets of miR-17-5p, such as inositol polyphosphate multikinase (IPMK)[53], polycystic kidney disease (PKD) [54], and phosphatase and tensin homolog (PTEN) [55], which may also be involved in regulating EC and C2C12 cell function. Here, IPMK is linked to polycystic kidney disease.