Through the study of HCC cell lines (Huh7, PLC/PRF/5, HCC cells T1115 and T1224) and models, researchers found non-cancer cell stem cells (non-CSCs) could secrete IL-25 into the tumor microenvironment, and secreted IL-25 interacts with IL-17RB on CSCs. The gene discussed is IL25; the disease is hepatocellular carcinoma.