In a study of T1D patients, the expression of IL-25 was found to be noticeably increased in the peripheral blood mononuclear cells (PBMC) of T1D patients compared to healthy individuals [130]; however, exogenous IL-25 could restore blood glucose levels in newly diabetic animals, and notably delay the recurrent autoimmune response after islet transplantation in the Non-Obese Diabetic (NOD) mouse model. Here, IL25 is linked to type 1 diabetes mellitus.