TP53 and cancer: There are more than 75 % of these mutations in TP53 that are missense mutations, which occur primarily in the DNA-binding domain and involve one amino acid change, including Y220C, G245C, R282W, R273H, R175H, R249S, and R248W, and lead to the high expression of full-length mutant p53 proteins (mutp53) that stably accumulate in cancer cells [5, 6].