BNIP3 and hepatocellular carcinoma: In this study, we further determined that BNIP3 and BNIP3L levels were negatively correlated with sorafenib resistance in sorafenib-resistant HCC (HCC-SR) cells due to promoter hypermethylation and found that MenSCs restored BNIP3 and BNIP3L expression in HCC-SR cells mainly through TET2-mediated active demethylation.