MST1 and diabetic cardiomyopathy: In a study using the mouse model of diabetic cardiomyopathy [25], the results showed that melatonin inhibited the expression of p-Mst1 and Mst1, and up-regulated the autophagy in myocardial tissue of diabetic mice, suggesting that melatonin may exert its cardio protective effect by inhibiting Mst1.