The two genes upregulated most in DIE compared to FA, Heat Shock Protein Family B (Small) Member 1 (HSPB1) and Calpain 2 (CAPN2), have not yet been described in endometriosis, despite the fact, that they play a role in proliferation and invasion in various solid tumors [42–45] and may serve this same function in DIE. Here, HSPB1 is linked to endometriosis.