PIK3CA and endometriosis: Previous work has also indicated dysregulation of the PI3K pathway in endometriosis: Yin et al. 2012 demonstrated an increase in pAKT, albeit in stromal cells from endometriomas, compared to cells from the eutopic endometrium of healthy women, and Guo et al. 2015 also showed that phosphorylated mTor is increased in ectopic endometrial lesions compared to eutopic endometrium from endometriosis patients [33, 34].