In addition, 15 among the 27 autoantibodies were significantly correlated with CDAI in ACPA− RA, with 8 (for SP1, TPM3, FRK, ELK1, CLK3, TPM1, DDIT3, and MARK3) and 7 (for VDR, CAPG, AHSG, CXCR4, EGR2, DCLK1, and ESR2) having positive and negative correlations with CDAI, respectively. The gene discussed is ESR2; the disease is rheumatoid arthritis.