TNF and systemic lupus erythematosus: As shown in Fig. 6E–H, enrichment of a number of pathways and cell types in both EA and AsA SLE cohorts were noted, including TLR signaling, inflammasome, TNF signaling and monocyte/myeloid lineage cells, whereas AsA patients exhibited additional enrichment in pro-cell cycle, low density granulocytes (LDGs) and B cells.