These results were confirmed in purified CD14+ monocytes isolated from EA and AsA SLE patients (California Lupus Epidemiology Study, CLUES; GSE16445721) (Supplemental Table S11) showing significant enrichment of gene signatures for oxidative stress, glycolysis and IFNA2, along with a trend toward elevated OXPHOS and mitochondrial dysfunction, specifically in AsA SLE patients (Fig. 7B). The gene discussed is IFNA2; the disease is systemic lupus erythematosus.