FN1 and neoplasm: Similar to the findings in Fn ATCC 23726, Cy3-labeled tsRNAs were also localized in the cytoplasm of two Fn clinical tumor isolates after 24 h incubation (Fig. S10), which further suggested that MOD(OMe)-tsRNAs entered Fn, regardless of their origins, to mediate the growth inhibition (Figs. 1C, 2B).