FN1 and neoplasm: Since the two MOD-tsRNAs can specifically kill Fn but spare other oral bacteria such as Pg and Sm, we further asked whether the selective killing by MOD-tsRNAs against Fn can be attributed to different uptake patterns in Pg and Sm. In contrast to their cytoplasmic accumulation in Fn ATCC 23726, Fn ATCC 25586 and clinical tumor isolates, the same MOD-tsRNA-Cy3 was primarily located at the periphery of Pg and Sm as evidenced by the Airyscan confocal microscopy imaging (Fig. 4D, Fig. S13).