Similarly, the NF-κB pathway was also significantly activated in response to JAK inhibition, which is known to drive cancer-related inflammation and tumor-promotion by myeloid cells in the tumor stroma43–46.Using the LISA Cistrome tool38, analysis of transcription factors potentially driving gene expression in ruxolitinib-treated macrophages demonstrated the RelA transcription factor to be the most common transcription factor associated with the upregulated genes (Fig. 2f). This evidence concerns the gene RELA and cancer.