STAT3 and lung carcinoma: It has also been shown that aldo-keto reductase family 1 member B1 (AKR1B1) interacts with signal transducer and activator of transcription 3 (STAT3) to up-regulate SLC7A11, which leads to increased Cys2 uptake in lung cancer cell lines and xenograft mouse models, and further promotes lung cancer cell resistance [80].