Indeed, exposure of PCLS from patients with fibrosis or end-stage cirrhosis to Ac-6-FP resulted in a decrease in MAIT cell activation and reduced the expression of fibrogenic genes, including COL1A1 and COL1A2, ACTA2, and TGFB1, together with the number of fibrogenic cells. This evidence concerns the gene ACTA2 and fibrosis.