In addition, the probiotic Lactobacillus rhamnosus GG, reduced hepatic fibrosis by inhibiting intestinal FXR signaling and decreasing FGF15 expression, and promoting the hepatic synthesis and excretion of bile acids, thus indicating that inhibition of intestinal FXR signaling may be of value as a strategy to alleviate hepatic fibrosis2. The gene discussed is NR1H4; the disease is Hepatic fibrosis.