P. distasonis was negatively correlated with the hepatic fibrosis indexes including alkaline phosphatase (ALP), total bile acid (TBA), Col1a1, tissue inhibitor of metalloproteinase-1 (Timp1), smooth muscle actin 2 (Acta2), transforming growth factor β (Tgfb) mRNA expression and severity degree (Child and MELD scores) in clinical samples and in mice (Supplementary Fig. 1b, c, Supplementary Fig. 2d). Here, COL1A1 is linked to Hepatic fibrosis.