Previously, the phase 1/2 dose escalation and cohort expansion study (RELATIVITY-020; NCT01968109) which also included patients with advanced melanoma who had failed or exhibited disease progression to anti-PD-1 therapy was able to prove favorable tolerability and long-term response to relatlimab plus nivolumab with an overall response rate (ORR) of 16% and disease control rate (DCR) of 45% [32]. Here, PDCD1 is linked to melanoma.