Clusterin also referred as apolipoprotein J (ApoJ), a small heat shock protein that acts as a molecular chaperone and promotes cell survival, has been largely reported in the literature associated with Alzheimer’s disease and other neurodegenerative diseases (Yuste-Checa et al. 2022; Jackson et al. 2019). This evidence concerns the gene CLU and early-onset autosomal dominant Alzheimer disease.