We found that while obstructive CAD associates with increased frailty index, older age and a cytokine signature characterized by IL-1β, IL-12p70 and IL-33, non-obstructive CAD is more likely to associate with a higher gender score and with a cytokine signature characterized by IL-18, IL-8, IL-23. This evidence concerns the gene CXCL8 and coronary artery disorder.