CHGA and Alzheimer disease: In fact, the significant increase of the ratios of chromogranin A to SV markers such as synaptophysin, p65 or SV2 in AD were significantly correlated to clinical severity of dementia [38] which prompted a speculation that distinct changes occur for SV and DCVs in AD with the caveat that DCV proteins are also present in the soma and their accumulation in AD may not necessarily reflect changes of DCVs in presynapse.