APOE and Alzheimer disease: GWAS (genome-wide association study) has identified about 40 loci associated with AD in the European population and in these respective loci, several genes involved directly in the causative mechanism of the disease have been described (APOE, CR1, BIN1, TREM2, CLU SORL1, ADAM10, ABCA7, CD33, SP11, PIRLA).