Further and in a recent work investigating the specific contributions of dietary fiber and mucin-degrading intestinal microbiota to the development of inflammation in Il10-deficient mice, low dietary fiber promoted bacterial erosion of the protective colonic mucus layer by mucin-degrading bacteria, resulting in lethal colitis mediated by Th1immune response, expansion of natural killer T cells and reduced levels of IgA-coated bacterial species [88]. This evidence concerns the gene CD79A and colitis.