Not only do SCD patients have higher leukocyte counts [44] and serum biomarkers of neutrophil activation, such as CD64 [45], CD11b/CD18 [46], and CD62L [37, 45, 46] compared to non-SCD individuals, their monocytes [47] and platelets [48] are also activated. This evidence concerns the gene ITGB2 and Schnyder corneal dystrophy.