The highest median SERINC5 down-regulation activity was observed in the Tshedimoso cohort (95%; IQR, 74–97%) followed by 86% (IQR, 68–92%) in the TRAPS cohort and 66% (IQR, 46–91%) in the HPP acute infection cohort, where there was a significant difference specifically between the Tshedimoso and HPP acute infection cohorts (Dunn’s multiple comparisons test; p < 0.001). The gene discussed is SERINC5; the disease is hypophosphatasia.