Cancer associated fibroblasts have also been shown to play multiple roles in tumor development by secreting growth factors, inflammatory ligands and extracellular matrix proteins that promote cancer cell proliferation and immune rejection [33].According to the TIMER database, we found that SNHG6 expression in KIRP was negatively correlated with macrophage abundance and positively correlated with cancer associated fibroblasts. The gene discussed is SNHG6; the disease is neoplasm.