Univariate analysis showed that age (HR,1.035; 95%CI, 1.012 ~ 1.058; p = 0.002), ECOG score (HR, 2.316; 95% CI, 1.361 ~ 3.939; p = 0.002), and CYFRA 21 − 1 (HR, 2.538; 95% CI, 1.509 ~ 4.268; p < 0.001) were associated with OS in advanced NSCLC patients with wild-type EGFR (Table 3). This evidence concerns the gene EGFR and non-small cell lung carcinoma.