In the present study, we retrospectively collected clinical and follow-up records on patients diagnosed with advanced NSCLC in our hospital and further analyzed the prognostic value of CYFRA 21 − 1 and Ki67 between 117 advanced NSCLC patients with wild-type EGFR and 37 advanced NSCLC patients with EGFR mutation. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.