NPPB and type 2 diabetes mellitus: Although the MIRAD trial used a NT-proBNP cut-of previously validated in type 2 diabetes [23], the cut-of is lower than what is currently used in HFpEF and HFrEF trials [32], and the resultant low proportion of diastolic dysfunction may reduce the study’s ability to detect a clinically relevant difference given the size and duration of the trial despite using high-dose therapy.