ICI combined with anti-VEGF antibody is known to have synergic effects due to the action of an anti-VEGF antibody on tumor microenvironment, including enhancing T-cell priming and activation via promotion of dendritic cell maturation, increasing T-cell tumor infiltration by normalizing tumor vasculature, and establishing an immune-permissive tumor microenvironment by decreasing myeloid-derived suppressor-cell and regulatory T-cell populations [25, 26]. Here, VEGFA is linked to neoplasm.