A depression animal model with cognitive dysfunction (chronic social defeat stress) demonstrated the downregulated expression level of TAAR1 in the mPFC,67 and the activation of this receptor may be beneficial to depressive symptoms in other mental disorders such as schizophrenia by increasing neural activity and upregulates the expression of plasticity‐related genes in prefrontal areas.30, 68. Here, TAAR1 is linked to mental disorder.