Both PRKDC and DNA‐PKcs affect tumorigenesis, progression, invasion and metastasis through different pathophysiological processes and further prognostic analyses have shown that DNA‐PKcs expression can help predict patient prognosis.Lu et al.24after studying the effect of DNA‐PKcs expression levels on clinical staging and lymphatic and distant metastasis of colorectal cancer, further demonstrated that DNA‐PKcs expression levels were negatively correlated with the 5‐year survival rate of patients. Here, PRKDC is linked to colorectal cancer.