Besides, epinephrine can upregulate the expression of circ‐HIPK3 through cAMP‐responsive element modulator (CREM), which in the long run promotes the progression of HF by increasing the concentration of Ca2+ in the cytoplasm of cardiomyocytes through the MiR‐17‐3p/adenylate cyclase type 6 (ADCY6) pathway.110. The gene discussed is ADCY6; the disease is hydrops fetalis.