MFN2 and Charcot-Marie-Tooth disease type 2A1: SARM1 has been shown to play a prodegenerative role in axonopathies characterized by mitochondrial dysfunction, such as CMT (Charcot-Marie-Tooth) disease type 2A caused by mutations in the MFN2 (mitofusin 2) gene (Loreto and others 2020; Sato-Yamada and others 2022).