In a study of the mechanism of action of the pyridine derivative vacor, a banned rodenticide and powerful neurotoxin associated with human nervous system disorders, Loreto and others (2021) showed that vacor neurotoxicity is predominantly SARM1 dependent and the Sarm1-/- neurons and axons are entirely resistant to death upon vacor treatment. The gene discussed is SARM1; the disease is nervous system disorder.