SARM1 and infection: Sarm1-/- mice exhibited decreased levels of TNF-α and increased viral replication and neuronal cell death after infection with WNV (Szretter and others 2009), and this increased susceptibility to WNV was recently confirmed in a CRISPR/Cas9-generated SARM1 null mouse that excluded contributions from any passenger mutations (Uccellini and others 2020).