For example, several studies have compared the efficacy of multiple GLP1-RAs, including EX, liraglutide, and semaglutide, in PCOS and found that they generally tend to promote weight loss, reduce the risk of cardiovascular disease, improve insulin sensitivity, improve hormone parameters, increase fertility, and enhance ovulation and pregnancy [27, 31, 57]. This evidence concerns the gene GLP1R and polycystic ovary syndrome.